Mechanism of Increase in Steatorrhea With Calcium and Magnesium in Exocrine Pancreatic Insufficiency: An Animal Model

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Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea?

BACKGROUND & AIMS Nutrients and properties of lipases affect survival of lipolytic activity during aboral gastrointestinal transit. Whether different doses and formulations of bacterial lipase and diets affect steatorrhea was tested in pancreatic-insufficient dogs. METHODS A dose of 0-600,000 IU of powdered and 135,000 and 300,000 IU of liquid bacterial lipase was given with a standard meal t...

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Pancreatic Exocrine Insufficiency in Pancreatic Cancer

Abstract: Cancer patients experience weight loss for a variety of reasons, commencing with the tumor's metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the ...

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Exocrine Pancreatic Insufficiency

Exocrine pancreatic insuffiency is loss of ability to properly digest food due to inadequate pancreatic enzyme activity. The etiology of exocrine pancreatic insuffiency, in humans, is mostly chronic pancreatitis or diseases affecting pancreas such as cytsic fibrosis, Shwachman-Diamond syndrome. It may also occur as a complication of gastric or pancreatic surgical procedures due to decrease of e...

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Exocrine pancreatic insufficiency in dogs and cats

In exocrine pancreatic insufficiency (EPI) there is insufficient production or secretion of digestive enzymes by the pancreas with associated maldigestion. Usually multiple enzymes need to be affected to show clinical disease, although there is one report of a patient with a lipase-only defect. Since lipase is the rate-limiting enzyme in pancreatic digestion, deficiency in just that single enzy...

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ژورنال

عنوان ژورنال: Gastroenterology

سال: 1982

ISSN: 0016-5085

DOI: 10.1016/s0016-5085(82)80201-1